48. Chemical Imbalance Revisited

On July 20, 2022 a review was published in the journal of Molecular Psychiatry. This review compiled 30 years of research into serotonin and depression in full showing little evidence of any abnormality of serotonin in people with depression.

welcome to the radically
genuine podcast dr roger mcfillin here with my

[sean]: brother shawn kelly is on vacation good
morning shawn we're aloud vacations only kelly okay

[sean]: well we kind of want to get
in the studio and address some recent events

[sean]: within the field of psychiatry psychology that
has certainly kind of taken the world by

[sean]: storm because is hit you international news
media and it's ironic because the very first

[sean]: podcast that we recorded was on this
very subject we thought it was that valuable

[sean]: in that important it was the around
the chemical and balance myth and when we

[sean]: first recorded that podcast many people would
have been surprised to hear these ideas that

[sean]: depression for example is not related to
low saratonian in the brain and therefore everything

[sean]: that we believe anti depressant to do
as far as correcting that low seratone in

[sean]: the brain is inaccurate and we've been
led to believe through very sis matic and

[sean]: targeted pharmasutical marketing campaigns to have us
believe that what we experience what we feel

[sean]: is related to an underlying brain abnormality
or an illness and in a recent review

[sean]: article in molecular psychiatry june july twentieth
came out very recent uh dr joanna moncrief

[sean]: and colleagues published this systematic review the
seratonan theory of depression a systematic umbrella review

[sean]: of the evidence anyone who wants to
get into the nitygrity details of such review

[sean]: feel free to i think for our
purposes today we just want to go over

[sean]: the highlights um very simply you know
the idea that depression is a result of

[sean]: abnormalities and brain chemicals in particular sarah
toning has been influential for decades and provides

[sean]: important justification for the use of anti
depressant what has the actual literature revealed and

[sean]: so when shan when we were recording
this podcast back in twenty twenty one june

[sean]: twenty twenty well probably fourteen months ago
fourteen months ago i just got finished with

[sean]: my own review and was surprised not
necessarily surprised but i was certainly shocked about

[sean]: how there was really no evidence at
all and we're all kind of subjected to

[sean]: media manipulation of idea yes and when
i knew very clearly that this was a

[sean]: you know a theory that was never
supported by evidence it became very important for

[sean]: us to be able to just start
communicating that that message and for me what

[sean]: was most concerning and forget about the
efficacy of anti depressence or any of the

[sean]: other effects the withdraw effects the the
side effects the long term impairment that exists

[sean]: from prolonged use i was most concerned
about was the psychological aspect of believing that

[sean]: there is something wrong with your brain
yes because of everything i know about the

[sean]: field of psychology and attempting to cope
and live well really reflect some core principles

[sean]: in how to you approach the the
experiences just being human and one of them

[sean]: is the idea that there are emotions
are there to serve us and when we

[sean]: feel something and we're experiencing something it
is something to be paid attention to because

[sean]: it is our body reacting to events
that occur in our life now those events

[sean]: could be outside of us or they
could be internal just our own thoughts our

[sean]: own our own memories and using those
emotions to our benefit is part of a

[sean]: very important adaptation process so i was
very concerned and always have been concerned about

[sean]: what happens then when you are led
to believe that what you are thinking or

[sean]: feeling is different than somebody else that
there's something you're broken in some way that

[sean]: that it's an illness and you'll never
know it was ever fixed or could be

[sean]: fixed yeah that's i would imagine that's
extremely challenging and difficult for someone to be

[sean]: in that position when you're told you're
broken and you have to do this for

[sean]: the rest of your life not only
that you have to really put trust into

[sean]: a physician who might only sit down
with you for thirty minutes forty minutes you

[sean]: know if that and just accept that
these are these are scientific advancements and you

[sean]: know there's clear validity to some of
the recommendations that are that are being made

[sean]: and so that's a lot of trust
right here take this farm a cuticle take

[sean]: this pill and you're going to feel
better over thirty plus years we've learned that

[sean]: you know most people don't feel better
and a lot get much much worse so

[sean]: where do things go from here and
what are our next steps when it's clear

[sean]: now that this has been disputed scientifically
i feel like it had been disputed scientifically

[sean]: for quite some time in a very
small niche of the psychiatry and psychological community

[sean]: of those that we're understanding the science
and it took this paper to take all

[sean]: of the research that existed compile it
into one concise statement that would finally say

[sean]: that that hypothesis for which ant depressant
were originally marketed under is not true therefore

[sean]: we need to investigate further it's basically
for me it was an if then statement

[sean]: right that's how i interpreted it so
i don't know if we actually said what

[sean]: the results were we just kind of
were going through the history of it can

[sean]: you can you reveal what the study
um what the final statement was for this

[sean]: umbrella review sure basically the main areas
of sara tone and research provide no consistent

[sean]: evidence of there being an association between
saratonian and depression no support for the hypothesis

[sean]: that depression is caused by lower carton
an activity or concentration some evidence was consistent

[sean]: with the possibility that long term anti
depression use actually reduces sara toning concentration and

[sean]: i don't think anyone argues or we'll
support the idea that depression is related to

[sean]: one nero chemical like sarah tone but
i think we'd all be concerned about what

[sean]: would happen for long term use if
you're unable to produce sarah tone so this

[sean]: this adaptation process of the brain when
you impact its own ability to produce a

[sean]: neuro chemical so we're certainly experimenting with
such a complex organ the brain what does

[sean]: then happen for prolonged ice so we're
at a point now where even though the

[sean]: majority these studies were very short term
definitely under twenty four weeks most eight to

[sean]: sixteen weeks we now have people on
the inside a presence for ten fifteen years

[sean]: or more multiple meditations which the combination
of has never been studied never studied so

[sean]: a lot of this is going to
be shocking to many people i remember when

[sean]: we recorded the first episode in here
this was all new to me i believed

[sean]: it to be true i thought you
were crazy and my approach in this room

[sean]: was to try and balance out many
of the conversations and make sure what was

[sean]: being said was was factual at least
debate with you a little bit so i

[sean]: could continue to learn and there by
others that were listening could learn as well

[sean]: and i look back now fourteen months
ago and i realize that m right it

[sean]: was it was a marketing campaign well
there's very good reason that you would have

[sean]: believed that and thought i was the
crazy one because of directed consumer marketing it

[sean]: really started in the nineteen nineties if
we we had this we played one of

[sean]: the commercials so i pulled it up
so we can we can listen to it

[sean]: again because of the language in there
and i always like to listen to the

[sean]: words that they used specifically right because
people hear what they want to hear and

[sean]: they believe it to be true but
i worked in advertising and we chose words

[sean]: very carefully so that we would never
ever get into legal trouble you know or

[sean]: i'm going to play this let's take
a listen about a minute long you know

[sean]: when you feel the weight of sadness
you may feel exhausted hopeless and anxious whatever

[sean]: you do you feel lonely and don't
enjoy the things you once love things just

[sean]: don't feel like they used to these
are some symptoms of depression a serious medical

[sean]: commission affecting over twenty million americans while
the cause is unknown depression may be related

[sean]: to an balance of natural chemicals between
nerve cells and the brain prescription zola works

[sean]: to correct this in balance you just
shouldn't have to feel this way any more

[sean]: only your doctor can diagnose depression so
loft is not for everyone people taking m

[sean]: s where pemiside shouldn't take solo side
effects may include dry mouth insomnia sexual side

[sean]: affects diario nausea and sleepiness zolofis not
having for talk to your doctor about zola

[sean]: the number one prescribed brand of its
kind zoloft when you know more what's wrong

[sean]: you can help make it right you
know when you okay there's the reason right

[sean]: and so what i started doing over
this past i guess year and a half

[sean]: as i wanted to ask people would
you have taken an anti depressing drug if

[sean]: you were told there is no such
thing as a chemical and balance have no

[sean]: evidence depression is associated with diminished sarah
to nan we have no evidence you have

[sean]: lower sarah to nan and we have
no idea what is going to happen to

[sean]: you long term would i absolutely not
so now so i ask questions like that

[sean]: to people i know impose those questions
on twitter one hundred per cent people come

[sean]: back no i would not have taken
this drug p questions always were you communicated

[sean]: to by doctor that this drug corrects
and underlying chemical or in balance or was

[sean]: it communicated to you in some way
that you may have a chemical balance the

[sean]: question is for a large the answer
was for a large majority absolutely so even

[sean]: though we didn't have the evidence shown
yeah doctors were still communicating this to patients

[sean]: because of a very very targeted marketing
campaign to physicians themselves with farmasutical sales people

[sean]: in the offices doctors were led to
believe that this drug does correct a underlying

[sean]: chemical abnormality and many to this day
are still communicating the same message if they

[sean]: are not in this field primary care
of physicians looking at close to eighty per

[sean]: cent of these drugs being prescribed by
primary care physicians certainly not reading the literature

[sean]: in sochiatry on depression probably not listening
to the radically genuine podcast they don't have

[sean]: patients in their office every day they
are just following protocols and they also have

[sean]: a broad knowledge base so take everything
in the medical field if you're a primary

[sean]: care physician or like a pediatrician you
have to understand what's happening in so many

[sean]: areas so you rely upon the expertise
of those that are providing literature to you

[sean]: in summary form so you can clearly
read digest understand repeat so you probably got

[sean]: an email from me this week and
actually send it out to the entire staff

[sean]: twelve email today was what this weekend
was a weekend where i was obsessively for

[sean]: gest on this subject because i have
plans you know i have i have ideas

[sean]: i think we have to actually i
think i have a responsibility to contribute more

[sean]: and one of those areas that i
think i need to contribute more is providing

[sean]: people informed consent and i have to
have a very extensive then knowledge of the

[sean]: literature base if i'm going to construct
something to be able to make an impact

[sean]: in this area so i'm going to
have to say i went through fifty plus

[sean]: papers on antidepressence for both adolescence and
an adult's teams adolescence and adults for the

[sean]: most part there there in the and
the past decade but when you read a

[sean]: scientific paper you kind of you can
go down the rabbit hole because you know

[sean]: each scientific paper might have fifty citations
so then you might just check out the

[sean]: citations in there yes and boy did
i have a headache i mean it was

[sean]: it was rough because you want to
know how did we get to this point

[sean]: because prescriptions are on the rise it's
not like they're declining they're actually the rise

[sean]: each year pharmasutical industry is going to
improve their customer base for psychiatric drugs especially

[sean]: when they tell people they don't have
they can't go off of them so then

[sean]: you like got that one moving on
to the next group that's a really good

[sean]: point because i didn't want to make
sure that i i miss this because it's

[sean]: really important especially from a safety perspective
this evidence has been widely distributed and is

[sean]: part of now the main stream to
hear in the united states which will get

[sean]: to in a second but it is
critically important to know that if you are

[sean]: taking anti de presence and you are
listening to this podcast or you read this

[sean]: study or you watched it on some
news channel do not abruptly stop your medication

[sean]: it could be deadly and we now
know that there is dependent c once you

[sean]: start these drugs if you abruptly start
stop them be a withdrawal reaction and for

[sean]: some people the withdrawal reactions are very
severe including increase suicideality um agitation sleep insomnia

[sean]: a number of things it's just a
very very dangerous process so consult your prescriber

[sean]: and if you are interested in starting
taper off these drugs you're going to want

[sean]: to do it in a very safe
science based way so don't just stop it

[sean]: especially for these people who have to
have been on this drug for quite some

[sean]: time because this umbrella review did not
look into anti depressant it was only looking

[sean]: at the causality effect of sarahtonan levels
and depression it's that needs to be like

[sean]: really clearly communicated because in the media
is getting misinterpreted and of course everybody s

[sean]: run in different directions with what the
interpretation yeah i think it's simply this a

[sean]: lot of people went on anti depressant
because it's influential because of the chemical and

[sean]: balance theory that's what they were led
to believe so once people learn that there

[sean]: is no ceratonan deficiency in fact some
people have more the level can be up

[sean]: and down and it depends on when
you're etting the test exactly you know like

[sean]: my guesses may be you did some
of the things that we were talking about

[sean]: like you're in the morning and you
do you you do your walk in the

[sean]: sun maybe you exercise then you meditate
and then you get a know some form

[sean]: of test to try to measure saratonanlevels
they might pay high right so it's yeah

[sean]: it's a it's very you want to
be very skeptical of the entire idea around

[sean]: saratonan or certain brain chemicals or even
thinking about depression as a brain disorder like

[sean]: just eliminate that thinking right now we're
talking about high levels of complexity when you're

[sean]: talking about the human experience a biological
psychological social spiritual nutritional perspective and we are

[sean]: a mystery in so many ways the
human experience is a mystery we haven't even

[sean]: begun to evolve the stage where we
can understand the complexity of such an experience

[sean]: that being said um this did bring
about some national recognition and as you would

[sean]: expect it became politicized unfortunately you're the
one who turned me onto the initial article

[sean]: article tell me about like how you
found that i was having my morning breakfast

[sean]: coffee over that weekend and apple news
and it got served to me probably because

[sean]: of my my search in recent history
has been focused on this industory so they

[sean]: probably saw this as a relevant story
for me and they kind of get bumped

[sean]: up and promoted and i was interested
why would the rolling stone be covering this

[sean]: topic and when i was reading the
rolling stone article it made me start to

[sean]: identify some key words that i was
interpreting as an attempt to mis credit the

[sean]: authors of the paper their position on
things in the past and um and ultimately

[sean]: what they were communicating in that rolling
stone actually in the in the umbrella report

[sean]: so what was being communicated in the
report was being misinterpreted and they were looking

[sean]: for others things that these authors had
said to almost align them with a very

[sean]: here in the united states a very
conservative right wing movement and trying to tie

[sean]: it to gun violence and that i
thought was an attempt to get people to

[sean]: ignore what this was trying to communicate
in the first place yeah it was in

[sean]: very poor taste not surprising because we've
we've broached topics such as this on our

[sean]: podcast previously especially how scientific ideas have
been high jacked play sized um but this

[sean]: is really disappointing because although i don't
know dr moncrief personally she's from the u

[sean]: k i'm very familiar with her work
and she is high le respected and she

[sean]: is in no way the type of
professional who is provocative she's quite measured and

[sean]: scientific certainly presents as as very compassionate
i believe she lives by that guiding principle

[sean]: of first do no harm there is
no doubt that she is a principled individual

[sean]: the highest ethical order and

[sean]: she did we'll get into this in
a second here if you if you look

[sean]: at any of her work she's a
she's a physician she's actually a psychiatrist right

[sean]: and she speaks about this know this
drug centered model u versus like a brain

[sean]: diseased model and she talks about realistically
and scientifically what the drugs actually do and

[sean]: why some people may report a benefit
but she unfortunately had to respond to that

[sean]: rolling stone article and we'll include that
in our show summary um and i'm bringing

[sean]: up the article right now she's pretty
much associated in the article some right wing

[sean]: ideology right so i'll just read the
the title of the article who is the

[sean]: psychiatrist behind the anti depress and study
taking over right wing meet and listen i've

[sean]: been looking at the various articles around
the world and there's certainly not limited to

[sean]: any political political perspective no not at
all so it says juandanna moncrefe has spent

[sean]: two decades questioning the efiqofefficacy of s
r s recently she's gone after covid nineteen

[sean]: vaccine mandates why connect this study to
covid nineteen vaccine mandates well it's been politicized

[sean]: politicized and trying you use the words
o misinformation high jack the word science among

[sean]: other things and so like trying to
communicate a message to people that if you

[sean]: question whatever the narrative that's that's presented
then you're a science denier and ultimately that's

[sean]: they're trying to discredit people um in
some ways as if they're you no conspiracy

[sean]: theorists um the truth of the matter
is r moncrief has always been clear about

[sean]: just presenting data as it exists and
then trying to inform people of what that

[sean]: data means and concern about this article
is they misrepresented a lot of her ideas

[sean]: and in some situations they were just
flat out lies and rolling stone magazine is

[sean]: a pretty influential cultural magazine in the
united states and there's there's no doubt that

[sean]: this comes across as a farm hit
piece i'm going to try to find a

[sean]: i'm going to try to get some
quotes from psychiatrist that they tried to support

[sean]: the previous narrative um m

[sean]: this paper is not coming in a
vacuum says as tab a clinical assistant professor

[sean]: of psychiatry at case western university who
previously interviewed moncrief in twenty twenty psychiatric times

[sean]: article it's coming with two decades of
work in which moncrief has consistently challenged the

[sean]: character ization of depression as a mental
illness that's a lie r moncrief very much

[sean]: communicates that being severely depressed is a
condition that requires intervention so they're shifting the

[sean]: language and correctly interpreting the thing she
said she actually does use medications in a

[sean]: very controlled way to in crises situations
when appropriate yeah and she's going to it's

[sean]: a she believes it's a decision that
needs to be made between a doctor and

[sean]: a patient best on best best avail
but evidence in which they're provided the potential

[sean]: risks and the potential benefits and it's
carefully monitored and so she's very clear about

[sean]: the potential benefits they tend to be
too thin s one when you take an

[sean]: anti depressant there is m you're inducing
a chemical in balance so you're inducing a

[sean]: physiological reaction so your body is going
to react to it the most notable one

[sean]: is blunting of emotion numbing numbing blunting
numbing and that includes both positive emotions and

[sean]: negative emotions so for a for a
small percentage of people especially if someone's feeling

[sean]: intensity of negative emotions that might be
initially interpreted as relief so we have to

[sean]: communicate that this could numb emotions much
like other drugs for some people if you

[sean]: smoke mariana or you drink alcohol they
can have similar effects everyone is different i

[sean]: was actually watch listening to a podcast
joe rogan podcast this this particular weekend where

[sean]: a someone that we've um you know
we've listened to previously and quoted on this

[sean]: podcast um m i'm forgetting his name
it's okay what was the message the message

[sean]: was that for some people for alcohol
it impacts their dopamenreceptors to differently and so

[sean]: they become highly elated and can continue
to drink for long periods of time with

[sean]: real elevated mood while other people it's
a sedative you know so for me i

[sean]: can have a couple of drinks and
it's relaxing yeah but if i have too

[sean]: many get tired the same way i'll
have you know at most two drinks now

[sean]: that's that's what two is my you
know it's my magic my comfort so everyone

[sean]: is different and we know that right
so there might be some people who take

[sean]: it in and to press it might
be in a high agitated state in a

[sean]: lot of emotional pain some emotional blunting
initially could have some potential positive interpreted improvement

[sean]: and improvement the other thing that she's
very clear of is they provide some people

[sean]: hope so it is the the placebo
response the belief that that i've found something

[sean]: to help me it's an exhale i'm
finally doing something about this and she recognizes

[sean]: how powerful that is the thing that
makes her really separate from many of her

[sean]: colleagues in the greater field and the
medical establishment she is very clear about what

[sean]: the risks are you know she'll be
open that with this drug centered model that

[sean]: in time the brain is going to
adapt and it will have an effect on

[sean]: the body right whether it's effect on
your metabolic health or your gutmicroiato or your

[sean]: brain a mysterious organ that we're still
learning about in time it certainly does increase

[sean]: to susceptibility and potentially a greater chance
of relapsing into further depressive episodes it does

[sean]: increase suicideality as we had on previous
podcasts we're learning about evidence regarding specific um

[sean]: m you know like genetic components and
like how how drugs are metabolized differently so

[sean]: bottom line as they affect people differently
and the overall research really it doesn't distinguish

[sean]: it much from a placebo response maybe
some short term response so bottom line is

[sean]: this is that she's she is not
the person that was presented in this article

[sean]: and it brings up a lot of
concern for me because um that that tells

[sean]: me that who's ever influencing this article
who's ever driving it certainly has an agenda

[sean]: and that agenda isn't science based that
agenda isn't looking out for the well being

[sean]: the health and the well being of
the populace i agree i agree if anything

[sean]: it just it separates you know we've
talked about putting people in the two camps

[sean]: it was establishing what camp are you
a part of that's that was how i

[sean]: was responding to reading that piece and
she's responded to it also because it was

[sean]: getting so many eyeballs she felt like
she really had it to or had to

[sean]: and this particular research study right now
is like the most downloaded research study it's

[sean]: been but like two or three weeks
and there's been millions of down loads so

[sean]: of course it's getting lots of attraction
as it should and she has taken a

[sean]: very appropriate path towards how to community
what it means i don't know where you

[sean]: want to continue to go in this
discussion but i read a couple of the

[sean]: other articles and i wrote down a
couple statements and i don't know a few

[sean]: i could read through them and you
can either say true false or we can

[sean]: comment on them or what are your
thoughts on to do it okay so i've

[sean]: already said that you know i interpreted
this entire study as an if then statement

[sean]: you know if the drugs were developed
to improve sara toni deficiency that's been proven

[sean]: not to be true then you know
what do the drugs do that was how

[sean]: she left it so number one is
that the research doesn't show that drugs aren't

[sean]: effective they only rule out one possible
way the drugs might work

[sean]: well i think we have decades of
studies shown that that show the drugs are

[sean]: not effective okay so too many physicians
are unwilling to take that leap because so

[sean]: many people are on them and the
moment you really proclaim that and you were

[sean]: somebody who wrote prescriptions and have been
part of that treatment for decades i think

[sean]: you're putting yourself in a precarious position
so i'm willing to say that because i've

[sean]: evaluated the research i don't believe the
drugs are anti depressence i don't think they

[sean]: have an effect on anti depressant something
that's really on anti depression something that's really

[sean]: interesting i got into an old article
um regarding what untreated depressive episodes look like

[sean]: okay and it's fascinating because what it
informs us is that depression has always been

[sean]: episodic so there is usually a time
limit to them and in particular it's when

[sean]: certain conditions resolve in your life right
could be loss of a job break up

[sean]: um a down period that exists you're
adapting when the conditions resolve themselves and your

[sean]: natural coping abilities allow you to overcome
them it's time limited so i think something

[sean]: like in his research eighty five percent
of all depressive episodes resolve themselves within twelve

[sean]: months most of them within three to
six so that means according to his research

[sean]: and i'll get that to you to
put in the show summer because i don't

[sean]: have the title with right now i
did post it on my twitter account this

[sean]: this weekend what that means is that
people are just inherently resilienthey're going to overcome

[sean]: those challenges on their own and if
you did not intervene they're going to improve

[sean]: i believe that to be true also
just based on this this you know people

[sean]: call we're not able to get to
everybody right away they go on the waiting

[sean]: list for people that get past ninety
days when we start calling them they say

[sean]: i no longer need your services ye
that's absolutely if they get an appointment elsewhere

[sean]: now i'm just i'm okay now good
and therefore this concept of wait fur watching

[sean]: is so important we've talked about that
before also so about there's going to be

[sean]: it just doesn't deny the fact that
depression in itself can be impairing and health

[sean]: condition to take seriously so there's about
fifteen per cent of people who are it's

[sean]: not gonna be episodic right it's going
to be prolonged there's probably various reasons for

[sean]: that and it's our responsibility in this
to identify how to intervene with them in

[sean]: a way that is most effective also
respects their autonomy and provides them the information

[sean]: because they're vulnerable right they're vulnerable for
for help so soon i don't believe that

[sean]: anti depressant work per se but i
am willing to say for a small percentage

[sean]: of people they interpret them for a
period of time as benefits that leads to

[sean]: my statement number two okay research suggests
anti depressant work only a bit better than

[sean]: placebo

[sean]: i'm gonna say that's false okay now
i want to expand upon that because in

[sean]: a in a study where it shows
a little bit better than placebo it's the

[sean]: law of averages within those that are
a little bit better than placebo there are

[sean]: some that are greater and some that
are less than you put them together the

[sean]: combined shows a little bit better than
very lowly so when you're talking about that

[sean]: in terms of it helps some people
the small percentage of those that it truly

[sean]: has helped would be into that group
that is a little that is better than

[sean]: placebo but most are at the placebo
level ye let me address that number one

[sean]: we're talking about better is a statistical
difference and interpretation it's a statistical difference on

[sean]: a a symptom check list yes the
best available evidence will say that statistical diff

[sean]: difference is not significant enough to have
any clinically relevant improvement in quality of life

[sean]: and i've taken the check list and
i know some of it is subjective based

[sean]: on how you're feeling at that moment
based on how tired you are did you

[sean]: get a good night sleep all that
stuff is factor into that so the other

[sean]: thing that's important to note is that
the this is fact that's the drug companies

[sean]: buried the studies that didn't demonstrate an
effect meaning they didn't publish them and that's

[sean]: called publication bias that you you publish
the studies that demonstrate in the fact and

[sean]: you don't in the ones that did
not support your intervention you put it all

[sean]: together my belief and this is from
my examination of the literature that they are

[sean]: a plus bo effect with side effects
got it statement number three there are many

[sean]: different expressions of depression that come from
a wide array of causal factors and present

[sean]: themselves differently from person to person absolutely
true absolutely in fact the idea of depression

[sean]: is just some social construct and an
umbrella term right so what one person might

[sean]: communicate as depression is just a use
of language and it's our limitations of language

[sean]: and while another person may deny that
exact same experience its depression at all it's

[sean]: a label it's trying to communicate something
that we are unable to investigate through direct

[sean]: observation so that leads to my next
statement there is no single treatment approach that

[sean]: works for everyone with depression absolutely true
okay so i was encouraged because as i

[sean]: was i stumbled upon something that's happening
in the u k and it may have

[sean]: just been in the last year or
so u k doctors have been told they

[sean]: should offer therapy exercise mindful this or
meditation to people with less severe cases of

[sean]: depression before trying medication

[sean]: i mean i think for for you
who's not been involved in this field um

[sean]: that sounds encouraging but i'm it goes
back to the language again less severe depression

[sean]: and how does one even define that
would be a doctor and a client understanding

[sean]: the circumstances and working closely kind of
like what joanna mon crave thoughts we're gonna

[sean]: have a small percentage that she feels
could truly benefit in a short period of

[sean]: time it's a huge challenge because there
is probably a very very small minute percentage

[sean]: of people who've been assigned the label
of depression who are impaired in ways that

[sean]: many of our listeners do not understand
could be catatonic states um just not leaving

[sean]: their home crying all the time and
each day as a fight to get through

[sean]: without ending their life to me that
is severe right and i think those people

[sean]: who are struggling to that extent and
have not been helped by other means should

[sean]: have every right go through any treatments
that are available including anti to presents or

[sean]: innovative drug treatments or nutritional diets or
whatever it takes right like you only got

[sean]: one life to live maybe and so
therefore yeah whatever it takes and i think

[sean]: in order to ease the suffering of
people should be you know creative and work

[sean]: with them collaboratively but i also it's
really important for me to communicate that that

[sean]: is not the percentage of people most
people who are receiving anti depressance and mental

[sean]: health treatment don't even meet that criteria
i think we have a distorted idea of

[sean]: what is actually severe depression the mag
ority of therapists out there who are working

[sean]: in community based settings are dealing with
mile to moderate even some of the more

[sean]: challenging or difficult cases still don't reach
that threshold so it's just been an expansion

[sean]: of the diagnostic h severity range that
you know too many people are being identified

[sean]: as having severe depression when in fact
m that's not what others are experiencing but

[sean]: it's jane because then you don't want
to ever invalidate someone's you can be you

[sean]: can be in a lot of emotional
pain and not be severely depressed and those

[sean]: lines have been blurred um in our
society and then you'll just see a lot

[sean]: of nonsense out there that say who
are you to determine what is severe depression

[sean]: or people are hiding it and u
and they're doing a really good job of

[sean]: hiding their emotional experience well how do
we study it and how do we have

[sean]: a science base around it if professionals
aren't able to distinguish between what is most

[sean]: impairing versus what might be a range
that exist and many of us might face

[sean]: and at one point in our in
our lives i agree i would imagine there's

[sean]: a number of individuals that are severely
depressed and fail to recognize and admit it

[sean]: and go about their lives just numb
to that fact yeah that goes into coping

[sean]: right so there are wide range of
coping styles and one one coping style is

[sean]: avoidance um and another coping style is
you know reflects around a denial of the

[sean]: experience not everyone is so connected and
in touch to what they're feeling and their

[sean]: experiencing and don't even have that concept
of depression in their their view point like

[sean]: their perspective doesn't even allow them to
understand what they're experiencing in that way so

[sean]: that's that there are many different forms
of expression that is one where others are

[sean]: very expressive yeah can i read a
quote i was looking for this quote earlier

[sean]: from this i've been stalling so yes
i'm glad you and this is what's disingenuous

[sean]: and this is what's concerning i'm going
to read the paragraph within the medical community

[sean]: the papers conclusions were nothing new david
hellerstein professor of clinical psychiatry at columbia university

[sean]: medical center and director of columbia pression
evaluation service explains that the ceratoneand hypothesis the

[sean]: idea that depression is caused by lowsrtoneand
levels a quaint and over simplified shorthand that

[sean]: has been superseded by other explanations and
clinical practice for decades now he said to

[sean]: the review was largely met with yawns
from the psychiatric community and reading it i

[sean]: was kind of thinking wow next she'll
tackle the discrediting of the black bile theory

[sean]: of depression he tells rolling stones you
smug i read you smug clown i right

[sean]: now and i want you to come
on to this podcast david hallerston i will

[sean]: reach out to you because that is
such an offensive comment because still on major

[sean]: websites around your profession they'll still talk
about it in the possibility of a chemical

[sean]: de balance chemical and balance most people
who have depression and are seeking out psychiatric

[sean]: medications still believe that to be true
our physicians in community based settings are talking

[sean]: to ants about sarah toning and depression
and that's how it's being treated in the

[sean]: in the psychiatric community you're still treating
it with s s r is selective sarah

[sean]: to nan up take inhibitors you are
talking about and associating the chemical and balance

[sean]: theory with the screading of the black
bile theory of depression how can you put

[sean]: yourself out there in a major news
outlet like rolling stone with such a stupid

[sean]: statement that's embarrassing and that is why
i have such a challenge working in this

[sean]: field when you make a statement like
that r a professor of clinical psychiatry a

[sean]: renowned university at columbia

[sean]: um hm so here's the one thing
that i like about joanna moncreave is the

[sean]: published paper came out on the twentieth
and she wrote a piece that she was

[sean]: directing everybody to where she takes it
basically step by step and she says basically

[sean]: was a title of her article actually
did a social media and it's how to

[sean]: take the news that depression has not
been shown to be caused by a chemical

[sean]: balance uh that to me is a
very responsible way of handling this and not

[sean]: attacking anyone but purely just to help
those who may misinterpret um so i think

[sean]: this is a good way to end
it not reading her thing but we've already

[sean]: touched on the important of informed consent
people reading the literature for themselves understanding what

[sean]: is communicated and then recognizing that the
next steps are not to independently make any

[sean]: decisions but to consult with physicians in
a responsible way to determine what their next

[sean]: steps may be because everybody's pressive situation
is unique and everyone is an individual their

[sean]: situations very drastically so how how can
we responsibly communicate what the next steps are

[sean]: for anyone who may be listening to
this tell you what it's you're using the

[sean]: right word being responsible and that's the
difference between someone of dr joanna moncrete's stature

[sean]: and character versus the gentleman from olumbia
is that she is going to continue this

[sean]: process on how to communicate it responsibly
to clients she also understand and i think

[sean]: through empathy that a lot of people
are going to hurt and feel a lot

[sean]: of resentment and distrust towards the greater
mental health field which i'm a part of

[sean]: and so she recognize is it with
compassion and she helps people to better understand

[sean]: the complexity of what might be happening
to them and gives them a more thorough

[sean]: clear directive on what these drugs actually
do and what are the potential risks ultimately

[sean]: that's what we're asking for we're just
asking for honesty we're asking to be able

[sean]: to communicate to people hey if you're
going to put something into your body you're

[sean]: going to start any form of treatment
or medical intervention that you're aware of what

[sean]: the potential negative outcomes exist might choose
to do it with those risks just based

[sean]: on how you're feeling right now but
it is your choice i'm here with you

[sean]: and that's just that's not the way
it's been in psychiatry psychiatry has has made

[sean]: statements that are you know really what
are ridiculous come at this point there you

[sean]: know they're going to be flected on
is absolutely ridiculous such as like considering what

[sean]: you're experiencing or feeling to be similar
to insolent for diabetes associating these drugs as

[sean]: as if they're life saving there's so
many messages that we've been exposed to over

[sean]: the last thirty years that are just
inaccurate they're harmful and they're certainly not standing

[sean]: the test of scientific scrutiny so we
have that responsibility and i like that word

[sean]: this cast has to be responsible i'm
certainly aware that people are listening and they've

[sean]: been on these sores for potentially decades
they might even prescribe them to their own

[sean]: children yeah the goal of this is
to get you to become more educated and

[sean]: to wear and then to make do
your own research and then to take the

[sean]: appropriate steps that are the best interest
of yourself or your loved ones it's important

Creators and Guests

Dr. Roger McFillin
Host
Dr. Roger McFillin
Dr. Roger McFillin is a Clinical Psychologist, Board Certified in Behavioral and Cognitive Psychology. He is the founder of the Conscious Clinician Collective and Executive Director at the Center for Integrated Behavioral Health.
Kel Wetherhold
Host
Kel Wetherhold
Teacher | PAGE Educator of the Year | CIBH Education Consultant | PBSDigitalInnovator | KTI2016 | Apple Distinguished Educator 2017 | Radically Genuine Podcast
Sean McFillin
Host
Sean McFillin
Radically Genuine Podcast / Advertising Executive / Marketing Manager / etc.
48. Chemical Imbalance Revisited
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